Cognitive profiles in Mild Cognitive Impairment (MCI) patients associated with Parkinson's disease and cognitive
Michele Pistacchi1, Manuela Gioulis2, Franco Contin3
1Neurology Service, Santorso Hospital, Garziere street 73, Santorso, Italy.
Background:
Mild cognitive impairment (MCI) is rapidly becoming one of the most common clinical manifestations affecting the elderly and represents an heterogeneous clinical syndrome that can be ascribed to different etiologies; the construct of MCI in Parkinson's disease (PD) (MCI-PD) is more recent but the range of deficits is still variable. Early recognition and accurate classification of MCI-PD could offer opportunities for novel therapeutic interventions to improve the natural pathologic course.
Objective:
To investigate the clinical phenotype of amnestic mild cognitive impairment (aMCI) and in patients with PD and MCI (MCI-PD).
Materials And Methods:
Seventy-three patients with aMCI and in 38 patients with MCI-PD were enrolled. They all underwent Mini-mental State Examination (MMSE), the Rey auditory-verbal learning test and the immediate visual memory (IVM) item of the Mental Deterioration Battery, the Rey auditory-verbal learning test included the Rey-immediate (Rey-I), and the delayed recall of the word list (Rey test deferred, Rey-D). The Geriatric Depression Scale (GDS) was used for mood assessment.
Results:
The results of the Rey-I and Rey-D and of the IVM item showed statistically significant differences between the aMCI and the MCI-PD group. The mean Rey-I and Rey-D score was significantly lower as well as the IVM score was higher in patients with aMCI than in those with MCI-PD, aMCI patients showed greater impairment in long-term memory, whereas more aMCI than MCI-PD patients had preserved attention, computation, praxis, and conceptualization.
Conclusions:
Our findings demonstrate that the cognitive deficit profile is specific for each of the two disorders: Memory impairment was a typical feature in aMCI patients while MCI-PD patients suffered from executive functions and visuospatial attention deficits.
Insights
Mild cognitive impairment (MCI) in Parkinson's disease (PD) differs from amnestic MCI. MCI-PD patients show executive and visuospatial deficits, while aMCI patients have memory impairments.
Area of Science:
- Neurology
- Cognitive Science
- Geriatrics
Background:
- Mild cognitive impairment (MCI) is a common condition in the elderly, with varying causes.
- MCI in Parkinson's disease (MCI-PD) is a recognized subtype with a variable range of cognitive deficits.
- Early identification of MCI-PD is crucial for developing targeted therapies.
Purpose of the Study:
- To differentiate the clinical phenotype of amnestic MCI (aMCI) from MCI in Parkinson's disease (MCI-PD).
Main Methods:
- Seventy-three patients with aMCI and 38 with MCI-PD were assessed.
- Cognitive function was evaluated using the Mini-mental State Examination (MMSE), Rey auditory-verbal learning test (Rey-I, Rey-D), and immediate visual memory (IVM) test.
- Mood was assessed using the Geriatric Depression Scale (GDS).
Main Results:
- Significant differences were observed in Rey-I, Rey-D, and IVM scores between the aMCI and MCI-PD groups.
- Patients with aMCI exhibited greater long-term memory impairment compared to MCI-PD patients.
- aMCI patients generally had better attention, computation, praxis, and conceptualization than MCI-PD patients.
Conclusions:
- The cognitive deficit profiles are distinct for aMCI and MCI-PD.
- Memory impairment characterizes aMCI.
- Executive function and visuospatial attention deficits are typical of MCI-PD.
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