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Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
Low cytotoxicity and clastogenicity of some polymeric aminophosphonate derivatives
Anton Kril1, Margarita Topashka-Ancheva2, Any Georgieva1
1Bulgarian Academy of Sciences, Institute of Experimental Morphology, Pathology and Anthropology with Museum , Sofia , Bulgaria.
Abstract:
Poly(oxyethylene aminophosphonate)s synthesized on the basis of biodegradable poly(phosphorester)s and Schiff bases were tested in vitro for antitumor activity against a panel of six human epithelial cancer cell lines, for cytotoxicity to mouse fibroblast cells and in vivo for clastogenicity and antiproliferative effects. The polymers showed lower cytotoxicity, both in vivo and in vitro and lower clastogenicity in vivo than the corresponding low-molecular aminophosphonates. The biological activities of the tested polymers correlate with their low in vitro antitumor activity.
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