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Updated: Apr 11, 2026

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Published on: August 16, 2018
Pharmacological investigations of new galantamine peptide esters
Dobrina Tsvetkova1, Nikolai Danchev2, Irina Nikolova2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia , Sofia , Bulgaria.
Abstract:
Galantamine hydrobromide (GAL) is a reversible acetylcholinesterase inhibitor, with properties to increase the concentration of acetylcholine in several brain structures. The aim of this study is to determine the effect of new galantamine peptide esters: 3,4-dichlorophenyl-alanil-leucil-glycine-galantamine (GAL-LEU) and 3,4-dichlorophenyl-alanil-valil-glycine-galantamine (GAL-VAL), on locomotor activity in mice and cognitive processes in experimental model of learning and memory in rats. The results showed that per oral administration of GAL-LEU in a dose of 3 mg per kg improved the cognitive processes by increasing the conditional avoidances and learning ability after the 5th day of application and preserved the memory at the 12th day of the study.
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