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Rowell's syndrome induced by terbinafine.
Aizuri Murad1, Emma Shudell1, Niall Mulligan2
1Department of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland.
BMJ Case Reports
|May 30, 2015
Summary
Terbinafine, an antifungal drug for nail infections, can cause skin reactions. This study details a rare overlap syndrome of cutaneous lupus and erythema multiforme linked to terbinafine use.
Area of Science:
- Dermatology
- Pharmacology
- Toxicology
Background:
- Terbinafine is a widely used systemic antifungal agent.
- It is primarily prescribed for onychomycosis (fungal nail infections).
- Cutaneous adverse effects associated with terbinafine have been documented.
Observation:
- This report describes a patient presenting with an overlap syndrome.
- The syndrome involved features of cutaneous lupus erythematosus and erythema multiforme.
- The condition was reportedly induced by terbinafine medication.
Findings:
- The patient exhibited a rare drug-induced hypersensitivity reaction.
- The clinical presentation suggested an overlap between lupus and erythema multiforme.
- Review of existing literature identified similar terbinafine-associated cases.
Implications:
- This case highlights a potential, albeit rare, severe cutaneous adverse effect of terbinafine.
- Clinicians should be aware of this potential overlap syndrome when prescribing terbinafine.
- Further investigation into the mechanisms of terbinafine-induced dermatological reactions may be warranted.
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