Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pleural Disorders: Types and Brief Description

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reversible Calcineurin Inhibitor-associated Sensorimotor Polyneuropathy in a Lung Transplant Recipient: A Case Report.

International journal of organ transplantation medicine·2022

Same author

Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up<sup>☆</sup>.

Annals of oncology : official journal of the European Society for Medical Oncology·2021

Same author

[Early-stage lung cancer: Is there still a role for surgery?]

Revue des maladies respiratoires·2020

Same author

Editor's Choice - Nationwide Analysis of Patients Undergoing Iliac Artery Aneurysm Repair in the Netherlands.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2020

Same author

Correction to: "Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up".

Annals of oncology : official journal of the European Society for Medical Oncology·2020

Same author

Nutritional status of neurologically impaired children: Impact on comorbidity.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2019

Search research articles

Related Experiment Video

Updated: Apr 11, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Malignant Pleural Mesothelioma : Rationale for a New TNM Classification.

C De Laet¹, A Domen, K J Cheung

¹Department of Thoracic and Vascular surgery, Antwerp University Hospital, Edegem (Antwerp), Belgium.

Acta Chirurgica Belgica

|May 30, 2015

Summary

This summary is machine-generated.

A revised staging system for malignant pleural mesothelioma (MPM) is needed due to limitations in the current TNM classification. An improved system will aid clinical trials and treatment comparisons for this rare thoracic cancer.

More Related Videos

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Related Experiment Videos

Last Updated: Apr 11, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Area of Science:

Oncology
Thoracic Surgery
Medical Diagnostics

Background:

Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer with a poor prognosis.
Accurate staging is crucial for diagnosis and treatment planning in MPM.
The current TNM staging system (7th edition) guides treatment decisions based on tumor extent, nodal involvement, and metastasis.

Purpose of the Study:

To address limitations of the current TNM staging system for MPM.
To optimize the staging system for current clinical needs.
To facilitate the development of improved diagnostic and treatment strategies for MPM.

Main Methods:

The International Association for the Study of Lung Cancer (IASLC) initiated a multi-center, prospective Mesothelioma Staging Project.
This project aims to overcome the limitations of the 7th edition TNM staging system.
The project focuses on refining the classification of tumor (T), nodes (N), and metastasis (M) for MPM.

Main Results:

The current TNM staging system's validity is questioned due to MPM's low prevalence and histological diversity.
The role of specific treatments, like surgery, in early-stage MPM requires further determination.
The Mesothelioma Staging Project seeks to provide a more accurate and current staging framework.

Conclusions:

An optimized staging system for MPM is essential for designing effective clinical trials.
Improved staging will enable better comparison of patient outcomes across different institutions.
This advancement will support the investigation of novel treatment strategies for mesothelioma.