Hyaluronan and its function as an unspecific regulator of cell-bound receptors

In a former study on primary mesangial cells a regulatory function of hyaluronan (HA) was shown. HA is the backbone of a cell-bound jelly-barrier. The thickness of that cell-bound jelly-barrier regulates the access of ligands to their cellular receptors in an unspecific way. The thickness of that barrier is reduced by degradation of HA. The hypothesis was that this regulatory mechanism is not restricted to mesangial cells, but applies for other cell types as well. A selective and topic oriented review of the literature was performed to collect references, which support the impression, that this unspecific mechanism of receptor-regulation by HA is not restricted to primary mesangial cells. On the basis of the data from the review of the literature it was concluded that the regulatory mechanism of HA also applies for other than mesangial cells. On the basis of the said mechanism it was concluded that a tissue-specific regulation of HA on the cell surface might be relevant in therapy, especially in chronic diseases.