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Differentiated thyroid carcinoma in early adulthood patients
J Younes1, C Ghorra, G Abadjian
1Department of General Surgery, Hotel Dieu de France Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Acta Chirurgica Belgica
|May 30, 2015
Summary
Differentiated thyroid carcinoma in young adults has a good prognosis, with rare disease-related deaths. However, recurrence is common, necessitating long-term patient follow-up for optimal management.
Area of Science:
- Endocrinology
- Oncology
- Surgical Pathology
Background:
- Differentiated thyroid carcinoma (DTC) is a common endocrine malignancy.
- Early adulthood represents a unique demographic for DTC presentation and management.
Purpose of the Study:
- To review the clinico-pathologic features and outcomes of DTC in patients aged 20-44 years.
- To compare DTC characteristics in early adulthood to the general patient population.
Main Methods:
- Retrospective study including 71 patients (20-44 years) undergoing thyroidectomy for DTC between 2000-2012.
- Data collected included demographics, pre-operative details, surgical parameters, post-operative values, complications, histology, and follow-up outcomes.
- Statistical comparison with an all-ages group was performed.
Main Results:
- The cohort comprised 59 females and 12 males, with a median age of 29 years.
- Papillary carcinoma was predominant (93%). Extrathyroidal invasion (44%) and lymph node involvement (37%) were higher than in the general population.
- Recurrence occurred in 10% of cases, with no disease-related deaths. Transient hypocalcemia (15%) and dysphonia (4%) were the most common complications.
Conclusions:
- DTC in early adulthood generally has a favorable prognosis.
- Despite low mortality, a significant rate of recurrence highlights the need for vigilant, long-term follow-up in this age group.
