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Updated: Apr 11, 2026

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
Published on: October 16, 2018
Deep Sequencing of HIV-1 in Cerebrospinal Fluid
Cheuk Yan William Tong1, Sinead Costelloe2, Jonathan Hubb3
1Department of Infection, Barts Health NHS Trust Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London.
Abstract:
Using deep sequencing, human immunodeficiency virus (HIV) resistance-associated mutations were detected as minority species in the cerebrospinal fluid (CSF) of 4 patients with higher HIV type 1 RNA load in CSF than in plasma, but not in 2 patients with higher plasma viral load. Deep sequencing could help our understanding of viral escape in the central nervous system.
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