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Purification and Expansion of Mouse Invariant Natural Killer T Cells for in vitro and in vivo Studies
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A party of three: iNKT cells in GVHD prevention

Annkristin Heine1, Peter Brossart1

  • 1UNIVERSITY HOSPITAL BONN.

Blood
|May 30, 2015
PubMed

In this issue of Blood, Schneidawind et al demonstrate that the adoptive transfer of CD4+ invariant natural killer T (iNKT) cells from third-party mice protects from lethal graft-versus-host disease (GVHD) through expansion of donor regulatory T cells (Tregs) in a murine model of allogeneic hematopoietic cell transplantation (HCT).

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