Glycosyl hydroperoxides: a new class of potential antimalarial agents
Barbara Szechner1, Anna Jaromin2, Silvia Parapini3
1Institute of Organic Chemistry of the Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Abstract:
Motivated by the antimalarial properties observed in organic peroxides, an extensive series of glycosyl hydroperoxides was prepared with the aim of identifying new bioactive molecules. Selected compounds were tested against a Plasmodium falciparum culture (chloroquine-susceptible strain D10 and chloroquine-resistant strain W2). Screening results indicated that the factors critical for antimalarial activity were the presence of a hydroperoxide moiety and solubility in water at pH 5.0. Moreover, the ability to inhibit β-hematin formation in vitro has been evaluated (BHIA Assay).
More Related Videos
Related Concept Videos
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
Peroxisomes
Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids
Autoxidation of Ethers to Peroxides and Hydroperoxides
Radical Oxidation of Allylic and Benzylic Alcohols


