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Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

Autoimmune encephalopathies.

Ming Lim¹, Yael Hacohen², Angela Vincent²

¹Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Level 6, West Wing, Oxford 3 9DU, UK; Children's Neurosciences, Evelina Children's Hospital @ Guy's and St Thomas' NHS Foundation Trust, King's Health Partners Academic Health Science Centre, Lambeth Palace Road, London SE1 7EH, UK.

Pediatric Clinics of North America

|May 30, 2015

Summary

This summary is machine-generated.

Antibody-mediated central nervous system diseases involve antibodies targeting neuronal proteins, causing diverse neurological symptoms. Immunotherapy offers significant benefits for many affected children and adults.

Keywords:

AQP4 Antibody Autoimmunity Encephalitis Immune-mediated Immunotherapy Limbic MOG N-methyl d-aspartate receptor VGKC-complex

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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Area of Science:

Neurology
Immunology
Neuroscience

Background:

Antibody-mediated central nervous system (CNS) diseases represent a growing and complex area within autoimmune neurologic disorders.
These conditions are clinically significant in both pediatric and adult populations.
Antibodies target cell-surface epitopes on neuronal or glial proteins, leading to neurological dysfunction.

Purpose of the Study:

To highlight the clinical significance and diagnostic features of antibody-mediated CNS diseases.
To discuss the varied clinical presentations and potential for phenotypic variation, especially in children.
To emphasize the therapeutic potential of immunotherapy in these disorders.

Main Methods:

Review of clinical manifestations associated with antibody-mediated CNS diseases.
Correlation of clinical signs with antibody targets and affected brain regions.
Evaluation of diagnostic indicators including neuroimaging and electrophysiology.
Assessment of treatment outcomes with immunotherapy.

Main Results:

Antibody binding to neuronal or glial targets results in focal or generalized clinical signs.
Symptoms can include seizures, movement disorders, autonomic dysfunction, and sleep disturbances.
Neuroimaging and electrophysiological findings can suggest specific antibody-mediated disorders.
Phenotypic variation exists, even in children with the same antibody.

Conclusions:

Antibody-mediated CNS diseases are a critical diagnostic consideration in neurology.
Diverse clinical presentations necessitate a comprehensive diagnostic approach.
Immunotherapy is an effective treatment strategy, leading to substantial patient improvement.