Multifocal adenomatous oncocytic hyperplasia in parotid glands with metastatic deposits or primary malignant...

Rare tumorous lesions involving both parotid glands were found in a 90-year-old man at autopsy. The clinical course held together with the histopathological features of the parotid alterations, make it likely that they present a multifocal adenomatous oncocytic hyperplasia. Areas of clear cells and occurrence of papillary malignant foci lead to various differential diagnostic considerations. Series of therapeutic irradiation to both parotid regions with a latency period of 15-35 years perhaps induced multifocal malignant transformation in the oncocytic hyperplastic parotid tissue.