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Updated: Apr 11, 2026

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
Published on: January 24, 2025
Neurosyphilis in psychiatric practice: a case-based discussion of clinical evaluation and diagnosis
Jennifer Gatchel1, Benalfew Legesse2, Safwan Tayeb3
1MGH/McLean Adult Psychiatry Residency Program, Boston, MA, USA; Department of Psychopharmacology, Massachusetts General Hospital, 15 Parkman Street, Wang, 812, Boston, MA 02114, USA.
Objective:
Neurosyphilis can present with a wide range of neuropsychiatric symptoms. Hence, psychiatrists need to be familiar with tests for syphilis screening and how to interpret syphilis serologic tests.
Methods:
We present four cases of patients with positive syphilis tests encountered in a psychiatric hospital.
Results:
Two cases were treated for neurosyphilis, while the other two cases did not have active syphilis infection despite positive results.
Conclusion:
We thus highlight the challenges encountered by psychiatrists in screening for and diagnosing cases of neurosyphilis.
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