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Serum Soluble Corin is Decreased in Stroke
Hao Peng1, Fangfang Zhu1, Jijun Shi1
1From the Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China (H.P., J.S., Y.L., W.H.); Department of Emergency, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China (F.Z., Z.Z., J.M.); Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China (J.S., Y.S., W.H.); and Department of Neurology, Anshan Changda Hospital, Anshan, China (X.H., D.Z., F.Z., Y.S.).
Insights
Lower serum soluble corin levels are associated with increased stroke risk in both men and women. This finding suggests soluble corin may play a role in stroke development.
Area of Science:
- Cardiovascular Research
- Neurology
- Biomarker Discovery
Background:
- Soluble corin levels are reduced in coronary heart disease.
- Cardiac dysfunction is linked to stroke risk.
- Circulating corin's role in stroke has not been previously investigated in humans.
Purpose of the Study:
- To investigate the association between serum soluble corin levels and stroke.
- To compare serum soluble corin in stroke patients and healthy controls.
- To analyze stroke risk associated with corin levels stratified by sex.
Main Methods:
- Study included 481 ischemic stroke patients, 116 hemorrhagic stroke patients, and 2498 healthy controls.
- Serum soluble corin and conventional stroke risk factors were measured.
- Analyses were conducted separately for men and women due to known sex-based variations in corin levels.
Main Results:
- Patients with ischemic and hemorrhagic stroke exhibited significantly lower serum soluble corin than controls in both sexes.
- Lowest corin quartiles were linked to substantially higher odds of ischemic and hemorrhagic stroke in men and women.
- Decreasing serum soluble corin levels correlated with increased stroke risk in both sexes.
Conclusions:
- Serum soluble corin is decreased in individuals with stroke.
- Reduced serum soluble corin may indicate a pathogenic role in stroke development.
Background And Purpose:
Soluble corin was decreased in coronary heart disease. Given the connections between cardiac dysfunction and stroke, circulating corin might be a candidate marker of stroke risk. However, the association between circulating corin and stroke has not yet been studied in humans. Here, we aimed to examine the association in patients wtith stroke and community-based healthy controls.
Methods:
Four hundred eighty-one patients with ischemic stroke, 116 patients with hemorrhagic stroke, and 2498 healthy controls were studied. Serum soluble corin and some conventional risk factors of stroke were examined. Because circulating corin was reported to be varied between men and women, the association between serum soluble corin and stroke was evaluated in men and women, respectively.
Results:
Patients with ischemic and hemorrhagic stroke had a significantly lower level of serum soluble corin than healthy controls in men and women (all P values, <0.05). In multivariate analysis, men in the lowest quartile of serum soluble corin were more likely to have ischemic (odds ratio [OR], 4.90; 95% confidence interval, 2.99-8.03) and hemorrhagic (OR, 17.57; 95% confidence interval, 4.85-63.71) stroke than men in the highest quartile. Women in the lowest quartile of serum soluble corin were also more likely to have ischemic (OR, 3.10; 95% confidence interval, 1.76-5.44) and hemorrhagic (OR, 8.54; 95% confidence interval, 2.35-31.02) stroke than women in the highest quartile. ORs of ischemic and hemorrhagic stroke were significantly increased with the decreasing levels of serum soluble corin in men and women (all P values for trend, <0.001).
Conclusions:
Serum soluble corin was decreased in patients with stroke compared with healthy controls. Our findings raise the possibility that serum soluble corin may have a pathogenic role in stroke.
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