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Published on: January 28, 2020
Serum Soluble Corin is Decreased in Stroke
Hao Peng1, Fangfang Zhu1, Jijun Shi1
1From the Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China (H.P., J.S., Y.L., W.H.); Department of Emergency, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China (F.Z., Z.Z., J.M.); Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China (J.S., Y.S., W.H.); and Department of Neurology, Anshan Changda Hospital, Anshan, China (X.H., D.Z., F.Z., Y.S.).
Lower serum soluble corin levels are associated with increased stroke risk in both men and women. This finding suggests soluble corin may play a role in stroke development.
Area of Science:
- Cardiovascular Research
- Neurology
- Biomarker Discovery
Background:
- Soluble corin levels are reduced in coronary heart disease.
- Cardiac dysfunction is linked to stroke risk.
- Circulating corin's role in stroke has not been previously investigated in humans.
Purpose of the Study:
- To investigate the association between serum soluble corin levels and stroke.
- To compare serum soluble corin in stroke patients and healthy controls.
- To analyze stroke risk associated with corin levels stratified by sex.
Main Methods:
- Study included 481 ischemic stroke patients, 116 hemorrhagic stroke patients, and 2498 healthy controls.
- Serum soluble corin and conventional stroke risk factors were measured.
- Analyses were conducted separately for men and women due to known sex-based variations in corin levels.
Main Results:
- Patients with ischemic and hemorrhagic stroke exhibited significantly lower serum soluble corin than controls in both sexes.
- Lowest corin quartiles were linked to substantially higher odds of ischemic and hemorrhagic stroke in men and women.
- Decreasing serum soluble corin levels correlated with increased stroke risk in both sexes.
Conclusions:
- Serum soluble corin is decreased in individuals with stroke.
- Reduced serum soluble corin may indicate a pathogenic role in stroke development.
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