Increases in plasma Tβ4 after intracardiac cell therapy in chronic ischemic heart failure is associated with
Fizzah A Choudry1, Chia Yeo1, Abdul Mozid1
11Department of Cardiology, London Chest Hospital, Barts Health Trust, London, E2 9JX, UK.
Aim:
Tβ4 is an integral factor in repair of myocardium in animal models. To investigate whether Tβ4 is important in human cardiac disease and has a role in mediating the beneficial cardiac effects of bone-marrow-derived stem cell (BMSC) therapy, we measured serial plasma Tβ4 levels in patients enrolled on the REGENERATE-IHD cell therapy trial.
Patients & Methods:
Plasma Tβ4 concentrations were measured in 13 patients who received BMSCs and 14 controls.
Results:
There was a significant increase in plasma Tβ4 in the BMSC group 24 h after intracardiac injection. Increases in Tβ4 levels were associated with improvement in New York Heart Association symptom class.
Conclusion:
This exploratory study highlights the need for further study of Tβ4 in human cardiovascular disease.
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