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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Grain and legume allergy.

Komei Ito1

  • 1Department of Allergy, Aichi Children's Health and Medical Center, Aichi, Japan.

Chemical Immunology and Allergy
|May 30, 2015
PubMed
Summary

Wheat and soybean allergies stem from distinct protein components. Different allergens cause varied reactions, from baker's asthma to anaphylaxis, impacting children and adults differently.

Area of Science:

  • Food allergy research
  • Immunology
  • Protein biochemistry

Background:

  • Wheat and soybean are common food allergens.
  • Wheat proteins include soluble fractions and gluten.
  • Soybean allergens are seed storage proteins or pollen-related.

Observation:

  • Wheat allergens like alpha-amylase/trypsin inhibitor cause baker's asthma.
  • Gluten allergens trigger exercise-induced anaphylaxis and immediate allergies.
  • Soybean allergens Gly m 5, 6, and 8 cause immediate reactions; Gly m 4 causes pollen-related allergy.

Findings:

  • Distinct allergen components in wheat and soybean lead to varied clinical manifestations.
  • Hydrolyzed wheat proteins and deamidated glutens present unique IgE-binding epitopes.

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  • Different soybean proteins (Gly m 4, 5, 6, 8) are responsible for distinct allergy types.

    • Implications:

    • Understanding specific allergens is crucial for accurate diagnosis and management of wheat and soybean allergies.
    • Further research into unique epitopes may lead to novel therapeutic strategies.
    • Clinical presentation of food allergies is directly linked to the specific allergenic proteins involved.