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Updated: Apr 11, 2026
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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
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Necrotizing enterocolitis in full term neonates: is there always an underlying cause?
Olivier Abbo1, Luke Harper1, Jean-Luc Michel1
1CHU Reunion, Saint Denis, Reunion.
Journal of Neonatal Surgery
|May 30, 2015
Summary
Necrotizing enterocolitis (NEC) in full-term neonates is rare, with a later onset than in premature infants. Some cases lack clear causes, indicating a potentially distinct pathogenesis requiring further study.
Area of Science:
- Neonatalogy
- Pediatric Surgery
- Gastroenterology
Background:
- Necrotizing enterocolitis (NEC) is a severe gastrointestinal condition primarily affecting premature infants.
- NEC in full-term neonates is uncommon, and its characteristics may differ from those in preterm infants.
Purpose of the Study:
- To review the experience with full-term neonates diagnosed with NEC.
- To compare the clinical characteristics of NEC in full-term neonates to existing literature.
Main Methods:
- Retrospective review of neonates born after 35 weeks of gestation diagnosed with NEC.
- Data collected from 2000 to 2012 in Reunion Island.
Main Results:
- 27 full-term neonates (12.4%) were diagnosed with NEC, with a mean gestational age of 36.8 weeks.
- The mean onset of NEC was 12.1 days after birth; 37.5% required surgery.
- The overall survival rate was 88.8%, with two patients needing long-term non-enteral nutrition.
Conclusions:
- NEC in full-term neonates is a rare condition with a later onset than in preterm infants.
- Underlying causes were identified in some cases, while others were idiopathic, suggesting varied pathogenesis.
- Further research is needed to understand this condition and reduce mortality.
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