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Related Experiment Video

Updated: Apr 11, 2026

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
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Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

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Quantifying the vitamin D economy.

Robert P Heaney1, Laura A G Armas2

  • 1R.P. Heaney is with Creighton University, Omaha, Nebraska, USA. L.A.G. Armas is with the Department of Medicine, Creighton University, Omaha, Nebraska, USA rpheaney@creighton.edu.

Nutrition Reviews
|May 30, 2015
PubMed
Summary

Vitamin D metabolism is complex, influenced by genetics and intake. Understanding its pathways and quantifying metabolites is crucial for determining optimal vitamin D (1,25(OH)2D) levels and ensuring adequate intake.

Keywords:
125-dihydroxyvitamin D25-hydroxyvitamin Dinflammationlactationobesityvitamin D

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Last Updated: Apr 11, 2026

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
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Area of Science:

  • Nutritional Biochemistry
  • Human Physiology
  • Metabolic Pathways

Background:

  • Vitamin D absorption and utilization are multifactorial, influenced by intake routes, chemical forms, and individual genetics.
  • Vitamin D transport in blood involves Gc protein with polymorphic alleles affecting binding affinity and ethnic distribution.
  • Existing knowledge on vitamin D's physiological roles requires further quantification of its metabolic pathways and dynamics.

Purpose of the Study:

  • To delineate the key entities and transitions within the vitamin D metabolic system.
  • To summarize current knowledge regarding the rates and quantities involved in vitamin D metabolism.
  • To infer physiological functions based on quantitative data and discuss implications for assessing vitamin D adequacy.

Main Methods:

  • Comprehensive literature review focusing on vitamin D metabolism, transport, and utilization.
  • Analysis of factors influencing vitamin D metabolite production and action (endocrine, autocrine/paracrine).
  • Examination of how varying supplement dosing affects serum metabolite profiles.

Main Results:

  • Identified multiple entry routes and chemical forms of vitamin D, with utilization varying by input, demand, and genetics.
  • Described the role of Gc protein alleles in vitamin D transport and their ethnic variations.
  • Highlighted the influence of physiological controls, stimuli, and tissue demand on metabolic consumption.

Conclusions:

  • A quantitative understanding of vitamin D's economy, including entities, mechanisms, and pathways, is essential for elucidating its physiological functions.
  • Variability in vitamin D supplementation response underscores the need for personalized assessment.
  • Further research quantifying vitamin D metabolism is critical for establishing accurate markers of nutritional adequacy.