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Related Concept Videos

Blood Typing01:10

Blood Typing

4.8K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
4.8K

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Related Experiment Video

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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Sequence-Based Typing for Platelet alloantigens.

Shun-Chung Pai1, Liang-In Lin

  • 1Taiwan Blood Services Foundation, Taipei, Taiwan.

Methods in Molecular Biology (Clifton, N.J.)
|May 31, 2015
PubMed
Summary

Human Platelet Antigen (HPA) typing is crucial for assessing alloimmunization risk. This chapter details using sequencing-based typing (SBT) for accurate HPA identification.

Area of Science:

  • Immunogenetics
  • Molecular Diagnostics

Background:

  • Human Platelet Antigen (HPA) typing is essential for managing patients at risk of HPA alloimmunization.
  • Current methods predominantly rely on DNA-based techniques for HPA assessment.

Purpose of the Study:

  • To describe the application of sequencing-based typing (SBT) for Human Platelet Antigen (HPA) typing.
  • To provide a detailed overview of SBT techniques in the context of HPA analysis.

Main Methods:

  • Detailed description of sequencing-based typing (SBT) protocols for HPA genotyping.
  • Focus on the practical implementation of SBT in clinical and research settings.

Main Results:

  • SBT offers a robust and accurate method for HPA typing.

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  • The chapter outlines the process of HPA identification using SBT.

    • Conclusions:

    • Sequencing-based typing (SBT) is a valuable technique for Human Platelet Antigen (HPA) typing.
    • This method aids in assessing the risk of HPA alloimmunization.