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Antibiotic resistance to Propionobacterium acnes: worldwide scenario, diagnosis and management

Kabir Sardana1, Tanvi Gupta, Vijay K Garg

  • 1Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.

Expert Review of Anti-Infective Therapy
|May 31, 2015
PubMed

Insights

Antibiotic resistance in Propionobacterium is high for many common drugs. Novel treatments and non-antibiotic options like zinc can prevent resistance and reduce reliance on antibiotics.

Area of Science:

  • Dermatology
  • Microbiology
  • Genetics

Background:

  • Antibiotic resistance in cutaneous Propionobacterium is a significant global health concern.
  • High resistance rates are observed for macrolides, trimethoprim/sulfamethoxazole, and clindamycin.
  • Tetracyclines and levofloxacin generally show lower resistance potential.

Purpose of the Study:

  • To review the current landscape of antibiotic resistance in cutaneous Propionobacterium.
  • To identify effective diagnostic methods for assessing resistance.
  • To explore alternative and novel therapeutic strategies with low resistance potential.

Main Methods:

  • Review of existing literature on antibiotic resistance patterns.
  • Discussion of genomic evaluation techniques, including 16S ribosomal RNA gene sequencing.
  • Analysis of resistance potential for various antibiotic classes and novel agents.

Main Results:

  • Macrolides, trimethoprim/sulfamethoxazole, and clindamycin exhibit high resistance.
  • Tetracyclines and levofloxacin demonstrate low resistance potential.
  • Subantimicrobial doxycycline preparations may not induce resistance.

Conclusions:

  • Accurate sampling and genomic analysis are crucial for resistance determination.
  • Novel agents like octadecenedioic acid, phytosphingosine, and resveratrol show promise.
  • Non-antibiotic approaches, including oral retinoids and zinc, can mitigate antibiotic dependence and prevent resistance.
Keywords:
16S RNA PCRBPONB-003T-3912acneazelaic acidbiofilmsclindamycinlauric acidlevofloxacinmacrolidesresistanceresveratrolretapamulin

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