Development and validation of the Cerebral Performance Categories-Extended (CPC-E)

Area of Science:

• Neurology
• Cardiology
• Rehabilitation Medicine

Background:

• Optimizing resuscitation after cardiac arrest (CA) requires validated functional outcome measures.
• The traditional Cerebral Performance Category (CPC) lacks psychometric validation for post-CA assessment.

Purpose of the Study:

• To establish the psychometric properties of a revised outcome measure: the CPC-Extended (CPC-E).

Main Methods:

• Content validity was established through expert input and literature review.
• Feasibility, intra-rater (IR), and inter-rater reliability (IRR) were tested using retrospective electronic medical record (EMR) review and in-person administration.

Main Results:

• The CPC-E has 10 domains; EMR review showed frequent missing data and variable reliability (ICC 0.46-0.93).
• In-person administration demonstrated no missing data and good to excellent IRR (ICC 0.79-1.00).
• Completion time for in-person administration was under 7 minutes.

Conclusions:

• The CPC-E is a valid and clinically feasible measure for post-CA impairment and disability.
• In-person administration of CPC-E yields superior data completeness and reliability compared to EMR review.