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Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
Published on: January 31, 2018
Differential genomic damage in different tumor lines induced by prodigiosin
Jeanne Cristina Lapenda Lins1, Maria Eliane Bezerra DE Melo2, Silene Carneiro DO Nascimento3
1Department of Antibiotics, Federal University of Pernambuco, Recife, Brazil jeannecantalice@gmail.com.
Abstract:
Prodigiosin is a secondary metabolite produced by Serratia marcercens. As this pigment is suggested to be a cancer drug, genotoxicity studies are necessary. The aim of the present investigation was to evaluate the genotoxic effects of prodigiosin on tumoral and normal cell lines, NCIH-292, MCF-7 and HL-60. A normal line BGMK was used as control. Genomic damage induced by prodigiosin was observed in all tumor lines as well as the control line. The pigment induced the formation of micronuclei in tumor cells. The present data confirm the antitumor potential of prodigiosin. However, these findings also raise concerns regarding its target-specific action, as genotoxic effects on normal cells also occurred.
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