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[Roles of different macrophage phenotypes in the pathogenesis of some human diseases]

V N Sakharov, P F Litvitsky

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |June 2, 2015
    PubMed

    Insights

    Macrophages are crucial for disease recovery and inflammation, with their function depending on their environment. This review explores their protective and pathogenic roles and the potential for reprogramming macrophage behavior.

    Area of Science:

    • Immunology
    • Cell Biology

    Context:

    • Macrophages exhibit diverse functions influenced by their microenvironment.
    • These functions range from promoting disease recovery to exacerbating inflammatory responses.

    Purpose:

    • To review the dual roles of macrophages in infectious and oncologic diseases.
    • To examine their pathogenic functions in inflammatory diseases.
    • To highlight opportunities for macrophage reprogramming.

    Summary:

    • Macrophages play a significant role in both healing and disease progression.
    • Their phenotype and function are dictated by the surrounding microenvironment.
    • Reprogramming macrophages presents a potential therapeutic strategy.

    Impact:

    • Understanding macrophage plasticity is key to developing novel treatments.
    • Targeting macrophage reprogramming could offer new avenues for managing inflammatory and oncologic conditions.
    • This review provides insights into the complex biology of macrophages.

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