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Updated: Apr 11, 2026
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Potentiodynamic Corrosion Testing
Published on: September 4, 2016
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Serum Metal Ions with a Titanium Modular Neck Total Hip Replacement System
1The Ottawa Hospital - Civic Campus, Ottawa, Ontario, Canada.
The Journal of Arthroplasty
|June 2, 2015
Summary
Serum metal ion levels (chromium, cobalt, titanium) increased within two years after total hip arthroplasty. Passive corrosion of non-articular surfaces may release more ions than implant interfaces.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Toxicology
Background:
- Total hip arthroplasty (THA) involves implanting artificial joint components.
- Concerns exist regarding metal ion release from THA implants into the bloodstream.
- Modular neck systems in THA may influence ion release profiles.
Purpose of the Study:
- To evaluate serum levels of chromium (Cr), cobalt (Co), and titanium (Ti) after THA.
- To compare ion release between metal-on-metal (MoM) and metal-on-polyethylene (MoP) bearing surfaces with a titanium modular neck.
- To investigate the primary sources of ion release in THA patients.
Main Methods:
- Prospective study involving 50 patients undergoing THA.
- Patients randomized to either MoM (CoCr shell) or MoP (Ti shell) bearing THA.
- Serum samples collected at baseline, 1 year, and 2 years post-surgery.
- Serum concentrations of Cr, Co, and Ti measured using validated analytical techniques.
Main Results:
- Significant increases in serum Cr, Co, and Ti levels observed at 1 year post-THA (P < .001).
- Titanium (Ti) levels were similar between MoM and MoP groups at 1 year (P=0.11).
- MoP group showed higher Ti levels than MoM group at 2 years (P=0.03).
Conclusions:
- THA with modular neck systems leads to elevated serum metal ion levels.
- Passive corrosion of exposed metal surfaces appears to be a significant source of ions.
- Further research is needed to understand the long-term clinical implications of these ion levels.
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