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Glycocalyx injury in adults with nephrotic syndrome: Association with endothelial function

Francisco Thiago Santos Salmito1, Fernanda Macedo de Oliveira Neves2, Gdayllon Cavalcante Meneses1

  • 1Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Ceara, Fortaleza, Ceara, Brazil.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|June 2, 2015
PubMed

Insights

Endothelial glycocalyx damage, indicated by increased syndecan-1, is present in nephrotic syndrome patients. This damage is linked to disease features and contributes to endothelial dysfunction.

Area of Science:

  • Nephrology
  • Cardiovascular Research
  • Vascular Biology

Background:

  • Glomerulopathy affects young adults, potentially leading to endothelial dysfunction, atherosclerosis, and cardiac issues.
  • The role of endothelial glycocalyx in nephrotic syndrome remains unevaluated.

Purpose of the Study:

  • To investigate endothelial glycocalyx integrity and endothelial function in patients with untreated primary nephrotic syndrome.
  • To assess the association between endothelial markers and nephrotic syndrome characteristics.

Main Methods:

  • Cross-sectional study of 49 patients with untreated primary nephrotic syndrome.
  • Measured syndecan-1, intercellular adhesion molecule-1 (ICAM-1), and e-selectin.
  • Assessed endothelial function using flow-mediated dilation (FMD).

Main Results:

  • Nephrotic patients exhibited reduced FMD compared to controls (3.7±1.7% vs. 6.6±1.1%, p<0.001).
  • Elevated levels of ICAM-1 (616.6±219.7 ng/ml) and syndecan-1 (180.3±64.1 ng/ml) were observed in nephrotic patients.
  • Syndecan-1 was independently associated with FMD after adjusting for clinical factors.

Conclusions:

  • Syndecan-1, a marker of endothelial glycocalyx damage, is elevated in nephrotic syndrome patients with preserved renal function.
  • Increased syndecan-1 correlates with nephrotic syndrome features, suggesting a role in endothelial dysfunction.
Abstract

Keywords:
EndotheliumGlomerulopathySyndecan-1

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