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Formulation and Stability Aspects of Nanosized Solid Drug Delivery Systems
1University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hogyes Endre Str. 7-9, H-1092 Budapest, Hungary. zelko.romana@pharma.semmelweis-univ.hu.
Current Pharmaceutical Design
|June 2, 2015
Summary
Nano drug delivery systems offer solutions for poorly soluble drugs, improving oral bioavailability. This review discusses lipid, polymeric, and inorganic nanoparticles for oral drug delivery, focusing on stability.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Nanotechnology
Background:
- Poor solubility, permeability, and bioavailability of drugs present significant challenges in pharmaceutical development.
- Nanosized drug delivery systems are being explored to overcome these limitations for oral administration.
Purpose of the Study:
- To review nanosized drug delivery systems for oral administration based on their chemical carrier nature.
- To highlight the potential of various nanoparticle types in enhancing drug delivery and overcoming bioavailability issues.
Main Methods:
- Discussion of lipid-based nanoparticles (SLNs, NLCs, hybrid particles).
- Review of polymeric nanoparticles (nanospheres, nanocapsules, fibrous systems).
- Exploration of inorganic nanoparticles (mesoporous materials, gold nanoparticles) and their functionalization.
Main Results:
- Lipid nanoparticles are effective for lipophilic drugs with poor oral bioavailability.
- Polymeric nanoparticles offer unique structural advantages for drug delivery.
- Inorganic nanoparticles provide precise control over particle characteristics through surface functionalization.
Conclusions:
- Nanosized drug delivery systems, including lipid, polymeric, and inorganic types, show great promise for oral drug formulation.
- The functionality-related stability of these systems is a critical factor for successful drug development.
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