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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Current treatment options for dermatofibrosarcoma protuberans.

Piotr Rutkowski1, Maria Debiec-Rychter

  • 1Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.

Expert Review of Anticancer Therapy
|June 2, 2015
PubMed
Summary
This summary is machine-generated.

Dermatofibrosarcoma protuberans (DFSP), a rare skin cancer, is best treated with surgery. Imatinib offers a new systemic therapy option for advanced or unresectable DFSP cases, potentially leading to curative remission.

Keywords:
dermatofibrosarcoma protuberansimatinibmolecular targeted therapyneoadjuvant therapytyrosine kinase inhibitor

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Area of Science:

  • Oncology
  • Dermatology
  • Genetics

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing dermal neoplasm.
  • DFSP development involves chromosome 17 and 22 rearrangements, up-regulating platelet-derived growth factor.
  • Metastases are uncommon, but indolent growth can lead to extensive local invasion.

Purpose of the Study:

  • To review the current management strategies for Dermatofibrosarcoma protuberans.
  • To highlight the role of systemic therapy, particularly imatinib, in advanced DFSP.
  • To discuss the future perspectives in DFSP treatment.

Main Methods:

  • Literature review of DFSP management.
  • Analysis of treatment outcomes with surgical resection, radiotherapy, and systemic therapies.
  • Focus on imatinib's efficacy in unresectable and metastatic DFSP.

Main Results:

  • Complete surgical resection with negative margins is the primary treatment for localized DFSP.
  • Adjuvant radiotherapy is considered for positive margins when re-excision is not possible.
  • Imatinib has shown significant activity in advanced DFSP, rendering some previously unresectable tumors operable and leading to remission.

Conclusions:

  • Surgical management remains the cornerstone for localized DFSP.
  • Imatinib represents a breakthrough systemic therapy for unresectable or metastatic DFSP, offering potentially curative options.
  • Further research into other tyrosine kinase inhibitors is limited, with imatinib as the current standard for advanced DFSP.