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Related Experiment Video

Updated: Apr 11, 2026

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage
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COMT genotype, gambling activity, and cognition.

Jon E Grant1, Eric W Leppink1, Sarah A Redden1

  • 1Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.

Journal of Psychiatric Research
|June 2, 2015
PubMed
Summary
This summary is machine-generated.

The Val/Val Catechol-O-methyltransferase (COMT) genotype is linked to higher rates of gambling disorder and poorer cognitive function in young adults. This genetic factor may influence impulsive behaviors and gambling symptoms.

Keywords:
COMTCognitionDopamineGamblingImpulsivityPlanning

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychology

Background:

  • Problem gambling is associated with cognitive impairments.
  • Catechol-O-methyltransferase (COMT) influences prefrontal cortex dopamine and is implicated in gambling-related cognitive dysfunction.

Purpose of the Study:

  • To investigate the association between COMT genotype and gambling symptoms and cognitive functioning in adults with varying gambling behaviors.

Main Methods:

  • 260 non-treatment-seeking adults (18-29 years) provided saliva for COMT val158met genotyping.
  • Subjects underwent clinical evaluations and neurocognitive assessments (decision-making, working memory, impulsivity).

Main Results:

  • The Val/Val COMT genotype was linked to a higher prevalence of gambling disorder (31.8%) compared to the Val/Met group (13.2%).
  • Val/Val genotype was associated with more gambling disorder criteria, increased gambling frequency, and worse performance on risk adjustment, delay aversion, and spatial working memory tasks.

Conclusions:

  • The Val/Val COMT genotype is associated with specific clinical and cognitive characteristics in young adults who gamble.
  • Genotyping may help predict the development of impulsive behaviors like gambling disorder and inform treatment outcomes.