Nickel-catalyzed reductive arylation of activated alkynes with aryl iodides
Stephanie C M Dorn1, Andrew K Olsen1, Rachel E Kelemen1
1Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY 14627, USA.
Abstract:
The direct, regioselective, and stereoselective arylation of activated alkynes with aryl iodides using a nickel catalyst and manganese reductant is described. The reaction conditions are mild (40 °C in MeOH, no acid or base) and an intermediate organomanganese reagent is unlikely. Functional groups tolerated include halides and pseudohalides, free and protected anilines, and a benzyl alcohol. Other activated alkynes including an amide and a ketone also reacted to form arylated products in good yields.
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