Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

775
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
775

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypophosphatemic Osteomalacia Caused by Adefovir-Induced Fanconi Syndrome.

Nuclear medicine and molecular imaging·2026
Same author

From molecular mechanisms to clinical applications: A comprehensive review of photobiomodulation in cancer treatment.

Photochemistry and photobiology·2025
Same author

Blue Light Inhibits Proliferation of Metastatic Cancer Cells by Regulating Translational Initiation: A Synergistic Property with Anticancer Drugs.

Photochemistry and photobiology·2023
Same author

Usefulness of cyclic thermal therapy and red blood cell scintigraphy in patients with chemotherapy-induced peripheral neuropathy.

The Korean journal of pain·2021
Same author

Evaluation of Photobiogoverning Role of Blue Light Irradiation on Viral Replication.

Photochemistry and photobiology·2021
Same author

Effect of Ursodeoxycholic Acid on the Biodistribution and Excretion of Technetium-99m Radiopharmaceuticals in Rat: A Potential Image Quality Enhancer.

Yonsei medical journal·2021

Related Experiment Video

Updated: Apr 11, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.7K

Size Control of (99m)Tc-tin Colloid Using PVP and Buffer Solution for Sentinel Lymph Node Detection.

Eun-Mi Kim1, Seok Tae Lim1, Myung-Hee Sohn1

  • 1Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Cyclotron Research Center, Institute for Medical Science, Biomedical Research Institute, Chonbuk National University Medical School and Hospital, Jeonju, Korea.

Journal of Korean Medical Science
|June 2, 2015
PubMed
Summary

This study developed easily synthesized nano-sized tin colloids for lymphoscintigraphy. Technetium-99m-tin colloid (99mTc-BPTC-50) showed promising results for sentinel lymph node detection.

Keywords:
99mTc-tin ColloidLymphoscintigraphyPolyvinylpyrrolidone (PVP)Sentinel Lymph Node

More Related Videos

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

9.5K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

1.1K

Related Experiment Videos

Last Updated: Apr 11, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.7K
Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

9.5K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

1.1K

Area of Science:

  • Radiochemistry
  • Nanotechnology
  • Nuclear Medicine

Background:

  • Colloidal particle size is crucial for sentinel lymph node mapping in lymphoscintigraphy.
  • Developing methods for synthesizing controlled nano-sized radiocolloids is essential for improved diagnostic imaging.

Purpose of the Study:

  • To develop facile methods for preparing technetium-99m-tin colloid with nanometer-scale particle sizes.
  • To evaluate the suitability of different stabilizers and buffers for controlling colloid size.
  • To assess the in vitro and in vivo behavior of the synthesized radiocolloids for sentinel node detection.

Main Methods:

  • Synthesis of technetium-99m-tin colloid using tin fluoride, sodium fluoride, poloxamer-188, and polyvinylpyrrolidone (PVP).
  • Adjustment of pH using phosphate or sodium bicarbonate buffers.
  • Characterization of colloid particle size and evaluation of in vitro and in vivo distribution and uptake in animal models.

Main Results:

  • Polyvinylpyrrolidone (PVP) effectively controlled colloid size within the nanometer range.
  • Technetium-99m-tin colloid stabilized with sodium bicarbonate and PVP (99mTc-BPTC-50, <20 nm) showed preferential bone marrow and kidney distribution.
  • Technetium-99m-tin colloid stabilized with phosphate buffer and PVP (99mTc-PPTC-30, >100 nm) primarily accumulated in the liver.
  • In rabbits, 99mTc-BPTC-50 demonstrated increasing sentinel lymph node uptake over time, unlike 99mTc-PPTC-30.

Conclusions:

  • Nano-sized tin colloids can be rapidly and easily synthesized using PVP.
  • The 99mTc-BPTC-50 formulation shows significant potential as a radiopharmaceutical for sentinel lymph node detection due to its favorable biodistribution and node uptake characteristics.