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T-cell lymphoblastic lymphoma presenting with pleural effusion: A case report
Xin-Liang He1, Fan Yu1, Tao Guo2
1Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Respiratory Medicine Case Reports
|June 2, 2015
Summary
T-cell lymphoblastic lymphoma (LBL) is a rare, aggressive cancer. Medical thoracoscopy with pleural biopsy and immunophenotyping proved essential for diagnosing this challenging T-cell LBL case.
Area of Science:
- Hematology
- Oncology
- Thoracic Surgery
Background:
- Adult lymphoblastic lymphoma (LBL) is aggressive, predominantly affecting young men.
- T-cell LBL (T-LBL) comprises up to 90% of adult cases, often presenting with mediastinal mass and effusions.
Purpose of the Study:
- To report a case of T-LBL in an 18-year-old male.
- To highlight the diagnostic utility of medical thoracoscopy and immunophenotyping in T-LBL.
Main Methods:
- Case report of an 18-year-old male with mediastinal mass and pleural effusion.
- Diagnosis confirmed via medical thoracoscopy, partial pleura biopsy, and immunophenotypic analysis (CD3+, TdT+, CD99+, CD20-).
Main Results:
- The patient was diagnosed with T-cell lymphoblastic lymphoma.
- Immunophenotyping was crucial for differentiating T-LBL from other malignancies.
- The patient had a poor prognosis, succumbing to the disease within 6 months.
Conclusions:
- Medical thoracoscopy is a safe and accurate diagnostic tool for pleural diseases.
- Pleural biopsy with immunophenotyping is essential for the definitive diagnosis of T-LBL.
