[The consumption of fibronectin content in coronary artery stenosis in dogs]

Changes in plasma fibronectin (Fn) content of the coronary sinus were observed in coronary artery stenosis of dogs. The results showed that coronary artery stenosis produced an acute inflammatory response and decreased Fn when coronary artery stenosis was more than 75%, which was associated with an increase in platelet aggregation and activation. Histopathologic examination confirmed the presence of damaged endothelial cell and capillary and showed the adhesion of leukocyte and platelet also. The results suggest that injured coronary artery may impair protective function in coronary circulation.