Related Experiment Video
Updated: Apr 11, 2026

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
Published on: February 8, 2022
Contrast Enhancement of the Right Ventricle during Coronary CT Angiography--Is It Necessary?
Madeleine Kok1, Bas L J H Kietselaer2, Casper Mihl1
1Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands; CARIM Cardio Vascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.
Insights
Enhanced right ventricle visualization during coronary CT angiography did not increase pathology detection. This study suggests omitting dedicated right ventricle enhancement in screening coronary CT angiography may be possible, simplifying procedures.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Cardiac CT
Background:
- Coronary CT angiography (CCTA) is crucial for diagnosing coronary artery disease.
- Optimizing visualization of cardiac chambers, including the right ventricle (RV), is essential for comprehensive assessment.
- The necessity of prolonged contrast media injection for improved RV visualization in CCTA remains debated.
Purpose of the Study:
- To evaluate the impact of dedicated RV enhancement on detecting RV pathology during CCTA.
- To assess RV enhancement levels and image quality in patients undergoing CCTA.
- To determine if RV pathology detection is significantly increased with enhanced RV visualization.
Main Methods:
- Retrospective analysis of 472 patients undergoing screening CCTA.
- Multidetector-row CT with individualized contrast bolus injection (P3T protocol).
- Assessment of RV enhancement (HU) and image quality; RV pathology was recorded.
Main Results:
- Good image quality achieved in 372 patients (mean RV enhancement 268 HU).
- RV pathology was detected in only three patients (0.63%), all with dilatation.
- No significant increase in RV pathology detection was observed with dedicated enhancement.
Conclusions:
- Dedicated RV enhancement during screening CCTA rarely leads to the detection of additional pathology.
- Observed RV dilatations might be detectable without specific RV enhancement protocols.
- RV enhancement can potentially be omitted in screening CCTA to streamline the examination.
Purpose:
It is unclear if prolonged contrast media injection, to improve right ventricular visualization during coronary CT angiography, leads to increased detection of right ventricle pathology. The purpose of this study was to evaluate right ventricle enhancement and subsequent detection of right ventricle disease during coronary CT angiography.
Materials And Methods:
472 consecutive patients referred for screening coronary CT angiography were retrospectively evaluated. Every patient underwent multidetector-row CT of the coronary arteries: 128x 0.6mm coll., 100-120kV, rot. time 0.28s, ref. mAs 350 and received an individualized (P3T) contrast bolus injection of iodinated contrast medium (300 mgI/ml). Patient data were analyzed to assess right ventricle enhancement (HU) and right ventricle pathology. Image quality was defined good when right ventricle enhancement >200HU, moderate when 140-200HU and poor when <140HU.
Results:
Good image quality was found in 372 patients, moderate in 80 patients and poor in 20 patients. Mean enhancement of the right ventricle cavity was 268HU±102. Patients received an average bolus of 108±24 ml at an average peak flow rate of 6.1±2.2 ml/s. In only three out of 472 patients (0.63%) pathology of the right ventricle was found (dilatation) No other right ventricle pathology was detected.
Conclusion:
Right ventricle pathology was detected in three out of 472 patients; the dilatation observed in these three cases may have been picked up even without dedicated enhancement of the right ventricle. Based on our findings, right ventricle enhancement can be omitted during screening coronary CT angiography.
More Related Videos
08:13In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
11:09High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Related Concept Videos
Imaging Studies for Cardiovascular System V: CT
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Acute Coronary Syndrome III: Diagnostic Studies
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Cardiac Catheterization III: Left Heart Catheterization