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Updated: Apr 11, 2026

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Published on: November 11, 2016
TRPC channel modulators and their potential therapeutic applications.
Neelima Khairatkar-Joshi1, Daisy M Shah1, Indranil Mukhopadhyay1
11Glenmark Research Centre, Glenmark Pharmaceuticals Ltd, MIDC, Mahape, Navi Mumbai 400 709, India.
Transient Receptor Potential Canonical (TRPC) channels are promising therapeutic targets for various diseases. This review covers patents on TRPC modulators from 2002-2014, focusing on their biology and therapeutic potential.
Area of Science:
- Ion channel research
- Pharmacology
- Medicinal chemistry
Background:
- Transient Receptor Potential Canonical (TRPC) channels are implicated in numerous diseases.
- TRPC channels are nonselective cation channels with seven isoforms (TRPC1-C7).
- TRPC channels are emerging as key therapeutic targets in various pathological conditions.
Purpose of the Study:
- To review patents on TRPC receptor modulators published between 2002 and 2014.
- To provide an overview of TRPC receptor target biology.
- To discuss small and large molecule modulators and their therapeutic potential.
Main Methods:
- Patent literature search for TRPC modulators (2002-2014).
- Analysis of TRPC receptor biology and target validation.
- Review of chemical entities targeting TRPC channels.
Main Results:
- Significant patent activity in TRPC modulator development from 2002-2014.
- Identification of diverse small and large molecule modulators.
- Exploration of TRPC channels for respiratory, neurological, cardiovascular, and pain disorders, as well as cancer.
Conclusions:
- TRPC channels represent a viable target class for therapeutic intervention.
- Ongoing research and patenting indicate substantial interest in TRPC modulators.
- Further development of TRPC-targeted therapies holds promise for unmet medical needs.
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