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The adiponectin levels and asthma control in non-obese children with asthma
Mahmut Dogru1, Sukriye Ozde, Alev Aktas
1a Department of Pediatrics , Zeynep Kamil Woman's and Children's Diseases Training and Research Hospital , Istanbul , Turkey and.
Insights
Lower adiponectin levels in non-obese children correlate with uncontrolled asthma. This finding suggests adiponectin may serve as a biomarker for assessing asthma control in this population.
Area of Science:
- Pediatric Pulmonology
- Endocrinology
- Allergy and Immunology
Background:
- Asthma control is crucial for managing pediatric respiratory health.
- Adiponectin, an adipokine, has been implicated in inflammatory processes, but its role in asthma control, particularly in non-obese children, requires further elucidation.
- Understanding factors influencing asthma control can lead to improved therapeutic strategies.
Purpose of the Study:
- To investigate the association between serum adiponectin levels and asthma control status in non-obese children with asthma.
- To compare adiponectin levels in asthmatic children with those in healthy controls.
- To identify potential biomarkers for predicting asthma control.
Main Methods:
- A cohort of 82 non-obese children with asthma and 28 healthy controls were enrolled.
- Serum adiponectin levels were measured using biochemical assays.
- Pulmonary function tests (spirometry) and allergy skin prick tests were conducted on asthmatic participants.
Main Results:
- No significant differences in adiponectin levels were observed between asthmatic children and healthy controls.
- Children with uncontrolled asthma exhibited significantly lower levels of adiponectin, FEV1, FVC, and FEV1/FVC compared to well-controlled and partially controlled groups.
- Higher sensitivity to Alternaria alternata was noted in the uncontrolled asthma group.
Conclusions:
- Serum adiponectin levels are not significantly different between non-obese asthmatic children and controls.
- Lower adiponectin levels are significantly associated with poorer asthma control in non-obese asthmatic children.
- Adiponectin may serve as a potential indicator for identifying uncontrolled asthma in this pediatric population.
Objective:
To determine the relationship between adiponectin levels and asthma control in non-obese asthmatic children.
Methods:
Eighty-two children with asthma who had been followed up in a single center were included. The control group included 28 children with no evidence of allergic disease. Adiponectin levels were analyzed in all children. Additionally, skin prick tests and pulmonary function tests were also performed in patients.
Results:
Three groups were designated with respect to asthma control as; well-controlled group (n = 28), partially controlled group (n = 34) and uncontrolled group (n = 20). There was no significant difference of gender, age, height, weight, BMI and adiponectin levels between study and control groups (p > 0.05). The duration of illness, presence of atopy and sensitivities to mite, pollens, dander and cockroaches were similar between the groups (p > 0.05). Adiponectin, FEV1, FVC, and FEV1/FVC levels were significantly lower in uncontrolled group (p < 0.05). Sensitivity to Alternaria alternata was significantly higher in the uncontrolled group (p < 0.05). In logistic regression analysis, as dependent parameter, adiponectin, FEV1, FVC and FEV1/FVC levels were found to be statistically significant for uncontrolled asthma.
Conclusion:
Adiponectin levels in non-obese asthmatics were not different from controls. Lower levels of adiponectin were associated with uncontrolled asthma. Low adiponectin level can therefore be used as an indicator of uncontrolled asthma.
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