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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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What is the Immune System?01:38

What is the Immune System?

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Overview
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Special Features of Adaptive Immunity01:20

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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Cell-mediated Immune Responses01:40

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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.8K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Apr 11, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

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Putting together the autoimmunity puzzle.

Antonio La Cava

    The Journal of Clinical Investigation
    |June 2, 2015
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    Summary
    This summary is machine-generated.

    This review explores the complex causes of autoimmune diseases, highlighting shared pathways that disrupt immune balance and self-tolerance. Understanding these mechanisms is key to developing new therapies for various autoimmune disorders.

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    Area of Science:

    • Immunology
    • Pathogenesis of Autoimmune Disorders
    • Immune Homeostasis

    Background:

    • Autoimmune diseases involve complex etiologies with multiple contributing factors.
    • Shared mechanisms and pathways are implicated in the development of autoreactive immune responses across different autoimmune disorders.
    • Loss of self-tolerance and imbalanced immune homeostasis are central to autoimmune pathogenesis.

    Discussion:

    • This review series examines the general concepts of how pathogenic autoimmune phenotypes develop and progress.
    • It delves into recent mechanistic advances in understanding autoimmune disease development.
    • The series integrates discussions on potential therapeutic strategies.

    Key Insights:

    • Multiple autoimmune disorders share common underlying mechanisms leading to immune dysregulation.
    • Understanding these shared pathways is crucial for a unified approach to autoimmune disease research.
    • The progression from normal immune function to pathogenic autoimmunity involves specific molecular and cellular events.

    Outlook:

    • Future research should focus on elucidating the intricate details of these shared pathways.
    • Translational science can leverage these insights to develop targeted therapies for diverse autoimmune conditions.
    • Continued investigation into immune homeostasis and self-tolerance is vital for advancing autoimmune disease management.