Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

$Interference and Diffraction$ 02:18

Interference and Diffraction

Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a resulting wave with enhanced amplitude is produced. This is known as constructive interference. In this case, the two waves interacting are in phase with each other.

IR Spectrum Peak Splitting: Symmetric vs Asymmetric Vibrations

IR Spectrum Peak Splitting: Symmetric vs Asymmetric Vibrations

Identical bonds within a polyatomic group can stretch symmetrically (in-phase) or asymmetrically (out-of-phase). Similar to hydrogen bonding, these vibrations also influence the shape of the IR peak. Generally, asymmetric stretching frequencies are higher than symmetric stretching frequencies. For example, primary amines exhibit two distinct IR peaks between 3300–3500 cm−1 corresponding to the symmetric and asymmetric N-H stretching, while secondary amines exhibit a single...

Electronic Distance Measuring Instruments

Electronic Distance Measuring Instruments

Electronic Distance Measuring Instruments (EDMs) are essential tools in modern surveying, offering precise distance measurements by emitting electromagnetic signals and calculating the time required for these signals to travel to a target and return. Two primary types of signals are used in EDMs — light waves and microwaves — each suited to specific environmental and distance requirements. Light-wave-based EDMs utilize either infrared or laser light, providing high accuracy over...

Infrared (IR) Spectroscopy: Overview

Infrared (IR) Spectroscopy: Overview

When electromagnetic radiation passes through a material, atoms or molecules transition from a lower to a higher energy state by absorbing radiation corresponding to the energy difference between the two states. The absorption of infrared (IR) radiation causes transitions between vibrational energy levels in a molecule. Therefore, IR spectroscopy is a useful analytical tool for determining the molecular structure of molecules.
Different compounds display unique properties due to their...

Raman Spectroscopy Instrumentation: Overview

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

Phase Contrast and Differential Interference Contrast Microscopy

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

AI/ML-Assisted SERS Biosensing for Biomolecular Detection: From Direct Spectral Response to Integrated Diagnostic Systems.

Biosensors·2026

Same author

Loss of ABCA3 disrupts lipid balance and leads to AMPK-dependent suppression of SREBP1 in glioblastoma stem cells.

Oncogene·2026

Same author

DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species.

Nature communications·2025

Same author

Physics-informed neural networks in support of modal wavenumber estimation.

The Journal of the Acoustical Society of America·2024

Same author

Predicting ocean pressure field with a physics-informed neural network.

The Journal of the Acoustical Society of America·2024

Same author

Treatment of a Large Defect Induced by Atrophic Nonunion of Femoral Fracture in a Dog with Autogenous Coccygeal Bone Grafting.

Veterinary sciences·2023

Search research articles

Related Experiment Video

Updated: Apr 11, 2026

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Scanning balanced-path homodyne I/Q-interferometer scheme and its applications.

Seang Hor Eang, Seunghyun Yoon, Jun Gyu Park

|June 2, 2015

Summary

A novel scanning interferometer scheme improves vibration rejection by 11 dB, enabling high-sensitivity phase and amplitude measurements for complex sample analysis, such as protein biochips.

More Related Videos

Quantum State Engineering of Light with Continuous-wave Optical Parametric Oscillators

Quantum State Engineering of Light with Continuous-wave Optical Parametric Oscillators

Published on: May 30, 2014

The Generation of Higher-order Laguerre-Gauss Optical Beams for High-precision Interferometry

The Generation of Higher-order Laguerre-Gauss Optical Beams for High-precision Interferometry

Published on: August 12, 2013

Related Experiment Videos

Last Updated: Apr 11, 2026

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Quantum State Engineering of Light with Continuous-wave Optical Parametric Oscillators

Quantum State Engineering of Light with Continuous-wave Optical Parametric Oscillators

Published on: May 30, 2014

The Generation of Higher-order Laguerre-Gauss Optical Beams for High-precision Interferometry

The Generation of Higher-order Laguerre-Gauss Optical Beams for High-precision Interferometry

Published on: August 12, 2013

Area of Science:

Optics and Photonics
Biomedical Engineering
Analytical Chemistry

Background:

Heterodyne interferometers are susceptible to environmental vibrations, limiting measurement sensitivity and stability.
Existing scanning interferometers face challenges in achieving high-speed, high-precision measurements for complex samples.

Purpose of the Study:

To adapt the balanced-path scheme for a scanning homodyne I/Q-interferometer.
To enhance common vibration rejection for improved measurement performance.
To demonstrate the utility of the improved interferometer for complex sample analysis.

Main Methods:

Implementation of the balanced-path scheme in a scanning homodyne I/Q-interferometer.
Comparative analysis of vibration rejection against the traditional heterodyne scheme.
Application of the developed interferometer for imaging protein biochip samples.

Main Results:

An 11-dB improvement in common vibration rejection was achieved compared to the heterodyne scheme.
High sensitivity and stability in phase and amplitude measurements were demonstrated.
Successful acquisition of phase and amplitude images for protein biochip samples was performed.

Conclusions:

The proposed scanning interferometer scheme offers superior vibration rejection, enabling high-performance measurements.
This advanced interferometer is highly effective for diagnosing samples requiring intricate analysis, including homogeneity and concentration-dependent phase differences.
The application to protein biochips highlights its potential in biomedical diagnostics and material characterization.