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Updated: Aug 14, 2026
Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
Both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. A case-control study
Caroline Jézéquel1, Fabrice Lainé1, Bruno Laviolle2
1CHU Rennes, Liver Unit, F-35033, Rennes, France; INSERM, CIC 1414, F-35033, Rennes, France.
Background & Aims:
Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI).
Methods:
We conducted a prospective case-control study comparing AMI in 12 DIOS patients and 12 overweight normoferritinemic subjects matched on BMI and age. All participants were phlebotomized until serum ferritin dropped ≤ 50μg/L.
Results:
The two groups were comparable with respect to metabolic abnormalities and differed according to serum ferritin levels only. AMI was significantly (p<0.0001) higher in DIOS (2.5g±0.7) than in controls (0.8g±0.3). No side effects were related to phlebotomies.
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