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Effect of Ambrex (a herbal formulation) on hematological variables in hyperlipidemic rats
Insights
Ambrex treatment in hyperlipidemic rats did not alter erythrocyte indices but increased white blood cell and lymphocyte counts, suggesting immune system enhancement without adverse hematological effects.
Area of Science:
- Pharmacology and Toxicology
- Hematology
- Cardiovascular Research
Background:
- Cardiovascular diseases are globally prevalent, with hyperlipidemia being a significant risk factor.
- Understanding the hematological effects of potential therapeutic agents is crucial for managing hyperlipidemia and related conditions.
Purpose of the Study:
- To investigate the impact of Ambrex on hematological parameters in a rat model of hyperlipidemia.
- To assess the safety and potential immune-modulating effects of Ambrex.
Main Methods:
- Eighteen rats were divided into three groups: control (normal diet), hyperlipidemic (high-fat diet), and hyperlipidemic treated with Ambrex.
- Hematological factors including White Blood Cell (WBC), Red Blood Cell (RBC), hematocrit (HCT), hemoglobin, and platelets (PLT) were analyzed using a digital cell counter.
- Specific erythrocyte indices and white blood cell differentials were also measured.
Main Results:
- Hyperlipidemia significantly increased platelet (PLT) count.
- Ambrex administration led to a significant increase in WBC, lymphocytes, and granulocytes.
- No statistically significant variations were observed in erythrocyte indices (e.g., MCHC, MCV, RDW) among the groups.
Conclusions:
- Ambrex treatment in hyperlipidemic rats did not induce significant adverse alterations in hematological factors.
- Ambrex demonstrated a potential to enhance white blood cell and lymphocyte concentrations, possibly by stimulating the immune defense mechanism.
Abstract:
Cardiovascular and related disorders are one of the most common disease prevailing all over the world. Hyperlipidemic condition have been largely considered in the treatment of cardiovascular diseases. The present study was carried out to investigate the effect of Ambrex on hematological factors in hyperlipidemic rats and untreated hyperlipidemic rats. In this study, eighteen rats were randomly divided into three groups of six animals each. The groups received normal diet (Control Group A) high fat diet (HFD group B) and Ambrex treatment (Group C). After the study period, White Blood Cell (WBC), Red Blood Cell (RBC), hematocrit (HCT), Hemoglobin, platelet (PLT), lymphocytes, monocytes, granulocytes, Mean Corpuscular Hemoglobin Concentration (MCHC), plateletcrit (PCT), Mean Corpuscular Volume (MCV), Platelet Distribution Width (PDW), red cell distribution-standard deviation (RDW-SD), red cell distribution-correlation variance (RDW-CV), micro red blood cell (pRBC), macroRBC were measured using digital cell counter (MS9-3s). Hyperlipidemia increases markedly the PLT count. Administration of Ambrex appeared to significantly increase WBC, Lymphocytes, granulocytes. However, erythrocyte indices does not show statistically significant variations among the test groups and control groups. The findings demonstrated that Ambrex does not cause any significant undesirable alterations in hematological factors in male rats. Ambrex also enhances white blood cell concentration and lymphocytes which probably stimulate the immune defense mechanism.
