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Radiosensitivity of drug-resistant human tumour xenografts
1Institute of Experimental Pathology, German Cancer Research Center, Heidelberg.
Abstract:
The radiosensitivity of three drug-resistant sublines of a human epidermoid lung carcinoma growing as xenografts in nude mice was investigated. Drug resistance to vincristine, actinomycin D and cisplatin was developed in vivo by repeated drug treatment. It was found that all three drug-resistant tumour lines were not cross-resistant to irradiation.