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Updated: Apr 11, 2026

Generation of Mice Derived from Induced Pluripotent Stem Cells
Published on: November 29, 2012
Pluripotency and Epigenetic Factors in Mouse Embryonic Stem Cell Fate Regulation
Lluis Morey1, Alexandra Santanach1, Luciano Di Croce2
1Center for Genomic Regulation, Barcelona, Spain Universitat Pompeu Fabra, Barcelona, Spain.
Abstract:
Embryonic stem cells (ESCs) are characterized by their ability to self-renew and to differentiate into all cell types of a given organism. Understanding the molecular mechanisms that govern the ESC state is of great interest not only for basic research-for instance, ESCs represent a perfect system to study cellular differentiation in vitro-but also for their potential implications in human health, as these mechanisms are likewise involved in cancer progression and could be exploited in regenerative medicine. In this minireview, we focus on the latest insights into the molecular mechanisms mediated by the pluripotency factors as well as their roles during differentiation. We also discuss recent advances in understanding the function of the epigenetic regulators, Polycomb and MLL complexes, in ESC biology.
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