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Updated: Apr 11, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
Published on: December 19, 2025
Diagnostic dilemmas in a patient with multivascular embolic stroke
C P A Delsing1, M van Duijnhoven, C Arnoldussen
1ICU, VieCuri Medical Centre, PO Box 1926, 5900 BX, Venlo, The Netherlands, Corinne.Delsing@radboudumc.nl.
Abstract:
We describe a patient admitted to the intensive care unit with aphasia, which was due to an embolic ischaemic cerebral stroke associated with a previously unknown patent foramen ovale. Eventually, this finding during echocardiography led us to the diagnosis of pancreatic cancer. The thrombotic complications of pancreatic cancer, in combination with a large, patent foramen ovale, support the mechanism of a paradoxical embolism through the patent foramen ovale as the cause of cerebral ischaemic stroke.
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