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Updated: Apr 11, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Lipid effects and cardiovascular disease risk associated with glucose-lowering medications
Barbara E Stähli1, Catherine Gebhard, Jean-Claude Tardif
1Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec, H1T 1C8, Canada, barbarastaehli@hotmail.com.
Abstract:
Diabetes is a global epidemic, associated with a high burden of complications and 4.6 million deaths annually worldwide. As a result of decreasing levels of physical activity and increasing rates of obesity, diabetes is shifting from a disease affecting the elderly to one that affects younger patients or even children. Thus, aggressive treatment and optimal control of risk factors is the key to improve outcomes in those patients. Accumulating evidence of the cardiovascular and lipid effects of glucose-lowering medications suggest that treatment efficacy in diabetes can be further improved. This review provides an overview of the lipid effects and cardiovascular disease risk of current anti-diabetic medications and highlights opportunities and challenges in clinical practice.
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