Normal values for water-perfused esophageal high-resolution manometry.

Area of Science:

• Gastroenterology
• Esophageal Physiology
• Diagnostic Manometry

Background:

• Established normal values for water-perfused esophageal high-resolution manometry (HREM) are lacking in many regions.
• Current practice often relies on solid-state HREM values, which may not be directly applicable.

Purpose of the Study:

• To determine and establish normative values for water-perfused esophageal HREM.
• To provide a reliable reference for esophageal motility analysis in healthy individuals.

Main Methods:

• Recruitment of 16 healthy volunteers with no history of digestive or esophageal symptoms.
• Performance of 22-channel water-perfused esophageal HREM.

Main Results:

• Defined 5th-95th percentile ranges for key parameters including UESRP, UESResP, CFV, DCI, DL, IBP, IRP 4s, LESRP, Es, and LESL.
• Calculated values for contractile front velocity (2.4-7.1 cm/s) and distal contractile integral (285-2820 mmHg.s.cm).

Conclusions:

• Normal values for key parameters (IRP 4s, DL, CFV) using water-perfused HREM align with other perfusion devices.
• Minor but significant variations exist compared to solid-state HREM values, necessitating caution when applying normative data.