Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Fever01:25

Types of Fever

1.5K
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
1.5K
Patterns of Fever01:26

Patterns of Fever

4.4K
Before understanding the types and patterns of fever, it is essential to know its phases.
4.4K
Increased Body Temperature01:25

Increased Body Temperature

7.7K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
7.7K
Methods of reducing fever01:22

Methods of reducing fever

1.6K
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.6K
Viral Meningitis01:18

Viral Meningitis

137
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
137
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

58
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
58

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DHA-Rich Algae Feed Modulates Atlantic Salmon Health, Microbiota and Stress Response.

Aquaculture nutrition·2026
Same author

Replacing fish oil with Tetraselmis chui microalgae biomass does not compromise rainbow trout health: Biochemical, histologic, antioxidant and immune gene expression.

Scientific reports·2026
Same author

Cytogenetic spectrum and clinical presentation of Klinefelter syndrome: A comprehensive study from South India.

Medical journal, Armed Forces India·2026
Same author

Calcium regulation of muscle spindle mechanosensory afferent function.

Experimental physiology·2025
Same author

Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration.

Nature communications·2025
Same author

Functional mapping of the molluscan brain guided by synchrotron X-ray tomography.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: Apr 11, 2026

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay
07:23

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay

Published on: June 9, 2011

19.1K

Fever of unknown origin.

Catharina Mulders-Manders1, Anna Simon2, Chantal Bleeker-Rovers2

  • 1Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands karin.mulders-manders@radboudumc.nl.

Clinical Medicine (London, England)
|June 3, 2015
PubMed
Summary

Fever of unknown origin (FUO) diagnosis remains challenging. A standardized protocol, including PET-CT, is recommended, but many cases remain undiagnosed, often resolving spontaneously.

Keywords:
FDG-PETFever of unknown originconnective tissue diseasediagnosisinfectionmalignancysystemic autoinflammatory diseasestreatment

More Related Videos

A Rapid Strategy for the Isolation of New Faustoviruses from Environmental Samples Using Vermamoeba vermiformis
09:27

A Rapid Strategy for the Isolation of New Faustoviruses from Environmental Samples Using Vermamoeba vermiformis

Published on: June 4, 2016

8.2K

Related Experiment Videos

Last Updated: Apr 11, 2026

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay
07:23

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay

Published on: June 9, 2011

19.1K
A Rapid Strategy for the Isolation of New Faustoviruses from Environmental Samples Using Vermamoeba vermiformis
09:27

A Rapid Strategy for the Isolation of New Faustoviruses from Environmental Samples Using Vermamoeba vermiformis

Published on: June 4, 2016

8.2K

Area of Science:

  • Internal Medicine
  • Diagnostic Imaging

Background:

  • Fever of unknown origin (FUO) has been defined for over 50 years but continues to present diagnostic challenges.
  • Initial evaluation focuses on identifying potential diagnostic clues (PDCs) to guide investigations.

Purpose of the Study:

  • To describe the definition, diagnostic workup, causes, and treatment of FUO.
  • To highlight the challenges and recommended approaches in managing FUO.

Main Methods:

  • The study outlines a diagnostic approach starting with PDCs.
  • In the absence of PDCs, a standardized protocol is advised, prioritizing PET-CT as the initial imaging modality.

Main Results:

  • Even with standardized protocols, a significant proportion of FUO cases in Western countries remain undiagnosed.
  • Treatment is diagnosis-dependent; antipyretics may be used for symptomatic relief when no cause is found.
  • Corticosteroids are generally not recommended without a diagnosis, particularly early in the evaluation.

Conclusions:

  • The prognosis of FUO is linked to its underlying cause.
  • Many patients with unexplained FUO experience spontaneous fever remission.
  • Effective management requires a systematic diagnostic approach and cautious treatment strategies.