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Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

245
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
245

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Hydrogels in ophthalmic applications.

Susanne Kirchhof1, Achim M Goepferich1, Ferdinand P Brandl1

  • 1Department of Pharmaceutical Technology, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|June 3, 2015
PubMed
Summary

Hydrogels offer versatile solutions for severe eye diseases, improving ophthalmic drug delivery and aiding in treatments for visual impairment. This review highlights their polymer applications in ophthalmology.

Keywords:
Contact lensesDrug deliveryHydrogelsIntraocular lensesOphthalmologyPolymersTissue engineeringVitreous substitutes

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Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Severe eye diseases cause visual impairment and blindness globally.
  • Current ophthalmic treatments, like eye drops, have limitations, especially for posterior eye segment diseases.
  • Advanced drug delivery systems and novel materials are crucial for effective ocular therapies.

Purpose of the Study:

  • To review the diverse applications of hydrogels in ophthalmology.
  • To emphasize the polymers used in hydrogels and their suitability for ocular drug delivery.
  • To explore hydrogels as potential vitreous substitutes and intravitreal drug delivery systems.

Main Methods:

  • Literature review of hydrogel applications in ophthalmology.
  • Analysis of polymer types and their properties for ocular use.
  • Examination of hydrogels in contact lenses, intraocular lenses, drug delivery formulations, and wound repair.

Main Results:

  • Hydrogels are highly versatile biomaterials with established and emerging ophthalmic applications.
  • Specific polymers are utilized to tailor hydrogel properties for different ocular needs.
  • Hydrogels show promise for vitreous substitution and targeted intravitreal drug delivery.

Conclusions:

  • Hydrogels represent a significant advancement in ophthalmic treatment modalities.
  • Their adaptability makes them suitable for a wide range of ocular applications, from lenses to drug delivery.
  • Further research into hydrogels will likely lead to improved therapies for vision-threatening eye conditions.