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Updated: Apr 11, 2026
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Immunochemical faecal occult blood test for colorectal cancer screening: a systematic review
M F Syful Azlie1, M R Hassan2, S Junainah3
1Ministry of Health Malaysia, Medical Development Division, MaHTAS, Health Technology Assessment Section, Level 4, Block E1, Complex E, Precint 1, Government Office Complex, 62590 Putrajaya, Malaysia. syful.azlie@moh.gov.my.
Abstract:
A systematic review on the effectiveness and costeffectiveness of Immunochemical faecal occult IFOBT for CRC screening was carried out. A total of 450 relevant titles were identified, 41 abstracts were screened and 18 articles were included in the results. There was fair level of retrievable evidence to suggest that the sensitivity and specificity of IFOBT varies with the cut-off point of haemoglobin, whereas the diagnostic accuracy performance was influenced by high temperature and haemoglobin stability. A screening programme using IFOBT can be effective for prevention of advanced CRC and reduced mortality. There was also evidence to suggest that IFOBT is cost-effective in comparison with no screening, whereby a two-day faecal collection method was found to be costeffective as a means of screening for CRC. Based on the review, quantitative IFOBT method can be used in Malaysia as a screening test for CRC. The use of fully automated IFOBT assay would be highly desirable.
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