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Published on: April 4, 2025
Implications of paraureteral diverticulum for the management of vesicoureteral reflux
Young Jae Im1, Yong Seung Lee1, Sang Woon Kim1
1Department of Pediatric Urology, Severance Children's Hospital, Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
Insights
Paraureteral diverticulum in children with vesicoureteral reflux is linked to delayed ureteral drainage and increased risk of recurrent urinary tract infections. This finding suggests a need for enhanced monitoring and treatment strategies for affected children.
Area of Science:
- Pediatric Urology
- Nephrology
- Radiology
Background:
- Vesicoureteral reflux (VUR) is a common condition in children.
- Paraureteral diverticulum is a potential but often overlooked finding in VUR management.
- The clinical significance of paraureteral diverticulum in VUR remains to be fully elucidated.
Purpose of the Study:
- To investigate the clinical importance of paraureteral diverticulum in VUR management.
- To analyze the association between paraureteral diverticulum and recurrent urinary tract infections (UTIs).
- To evaluate the relationship between paraureteral diverticulum and delayed ureteral drainage.
Main Methods:
- Retrospective review of 131 children diagnosed with VUR.
- Diagnosis of VUR and paraureteral diverticulum using voiding cystourethrography.
- Analysis of delayed ureteral drainage and recurrent UTIs in relation to paraureteral diverticulum.
Main Results:
- Paraureteral diverticulum was present in 27.2% of refluxing ureters.
- Ureters with paraureteral diverticulum showed significantly higher rates of delayed ureteral drainage (92.7%).
- Paraureteral diverticulum was independently associated with delayed ureteral drainage (OR 11.47) and increased risk of recurrent UTIs (P=0.020).
Conclusions:
- Paraureteral diverticulum in VUR patients increases the risk of recurrent febrile UTIs.
- These findings highlight the clinical importance of identifying paraureteral diverticulum in VUR.
- Consideration of more progressive surveillance and treatment protocols for these patients is recommended.
Objectives:
To investigate the clinical importance of paraureteral diverticulum in the management of vesicoureteral reflux by analyzing the relationship between paraureteral diverticulum and recurrent urinary tract infections.
Methods:
We retrospectively reviewed 131 children diagnosed with vesicoureteral reflux. We diagnosed vesicoureteral reflux and paraureteral diverticulum by initial voiding cystourethrography and defined "delayed ureteral drainage" as the presence of contrast media in the upper urinary tract on delayed films after voiding. We analyzed the relationships between paraureteral diverticulum, delayed ureteral drainage and recurrent urinary tract infections.
Results:
The mean age at diagnosis of vesicoureteral reflux was 20.7 months. Of the 202 refluxing ureters, 55 (27.2%) had a paraureteral diverticulum. Of the 55 ureters with paraureteral diverticulum, 51 (92.7%) showed delayed ureteral drainage of refluxing contrast, which was significantly higher than the percentage of delayed ureteral drainage in ureters without paraureteral diverticulum (P < 0.001). On multivariate analysis of the effect of reflux grade or paraureteral diverticulum on delayed ureteral drainage of refluxing contrast, the odds ratio of paraureteral diverticulum was 11.47 (P < 0.001). In addition, the risk of recurrent urinary tract infections increased in ureters with paraureteral diverticulum (P = 0.020).
Conclusions:
In patients with vesicoureteral reflux and paraureteral diverticulum, the risk of recurrent febrile urinary tract infections seems to increase. Therefore, more progressive surveillance and treatment protocols should be considered in these patients.
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