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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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A Polymeric Bowl for Multi-Agent Delivery.

Dong Choon Hyun1

  • 1Department of Polymer Science, Kyungpook National University, 1370, Sankyuk-dong, Daegu, Korea.

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Summary
This summary is machine-generated.

This study presents a novel biodegradable polymer particle system for controlled multi-agent delivery. The system allows independent release tuning of hydrophobic and hydrophilic agents through adjustable sealing and nanoparticle encapsulation.

Keywords:
combined therapycontrolled releasehollow particlesmulti-agent delivery

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Developing sophisticated delivery systems is crucial for targeted therapeutic applications.
  • Controlling the release kinetics of multiple agents simultaneously presents a significant challenge.

Purpose of the Study:

  • To design and characterize a simple, biodegradable polymer particle system for multi-agent delivery.
  • To demonstrate independent control over the release profiles of hydrophobic and hydrophilic agents.

Main Methods:

  • Fabrication of hollow biodegradable polymer particles with a sealable surface hole.
  • Encapsulation of a hydrophobic dye (Nile Red) in the particle shell.
  • Encapsulation of a hydrophilic agent (Methylene Blue) in the hollow interior.
  • Controlled release studies under varying conditions and using encapsulated nanoparticles.

Main Results:

  • Sustained release of the hydrophobic dye from the particle shell.
  • Fast release of the hydrophilic agent from the hollow interior.
  • Independent modulation of release profiles by encapsulating hydrophilic agent-loaded nanoparticles within the hollow core.

Conclusions:

  • The developed polymer particle system offers a versatile platform for tunable multi-agent delivery.
  • The system allows for independent control over release rates of different agents, enhancing delivery precision.
  • Biodegradable polymer particles with sealable openings provide a simple yet effective approach for advanced drug delivery applications.