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Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

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Nocturnal periodic limb movements decrease antioxidant capacity in post-stroke women.

C-Y Chen^1,2, C-C Yu^2,3, C-L Chen^4,5

¹Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, Taiwan.

Acta Neurologica Scandinavica

|June 3, 2015

Summary

This summary is machine-generated.

Periodic limb movements during sleep (PLMS) are linked to lower antioxidant capacity in women with ischemic stroke. Higher PLMS index also correlates with increased stroke recurrence risk.

Keywords:

brain infarction inflammation oxidative stress periodic limb movements during sleep total antioxidant capacity

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Area of Science:

Neurology
Sleep Medicine
Cardiovascular Research

Background:

Periodic limb movements during sleep (PLMS) are implicated in cardiovascular risk and stroke outcomes.
The underlying mechanisms linking PLMS to stroke pathogenesis are not well understood.

Purpose of the Study:

To investigate the association between PLMS and biomarkers of oxidative stress and inflammation in ischemic stroke patients.
To explore the relationship between PLMS severity and stroke outcomes, including recurrence.

Main Methods:

A cross-sectional study involving 112 ischemic stroke patients admitted to a rehabilitation ward.
Polysomnography was used to assess PLMS index.
Laboratory tests measured inflammatory (C-reactive protein, interleukin-6) and oxidative stress biomarkers (total antioxidant capacity, 8-hydroxy-2-deoxyguanosine).

Main Results:

Patients with higher PLMS index (≥15) were older, had higher stroke severity scores, and lower functional independence.
Total antioxidant capacity (TAC) levels differed significantly across PLMS index groups.
PLMS index was negatively correlated with TAC in women and independently associated with an increased risk of stroke recurrence.

Conclusions:

PLMS is independently associated with reduced antioxidant capacity in women following ischemic stroke.
Higher PLMS severity may predict poorer stroke outcomes and increased recurrence risk.